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    • Showing Current items.

    pept-2 Peptide transporter family 2 [ Caenorhabditis elegans ]

    Gene ID: 177973, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pept-2
    Official Full Name
    Peptide transporter family 2
    Primary source
    WormBase:WBGene00003876
    Locus tag
    CELE_C06G8.2
    See related
    AllianceGenome:WB:WBGene00003876
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dipeptide transmembrane transporter activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in membrane. Predicted to be active in apical plasma membrane. Is expressed in anal depressor muscle; anal sphincter muscle; pharyngeal muscle cell; and vulval muscle. Orthologous to human SLC15A1 (solute carrier family 15 member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pept-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    17
    Sequence:
    Chromosome: IV; NC_003282.8 (10790653..10794559)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Serpentine receptor class delta-7 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of promoter elements of parasite nematode genes in transgenic Caenorhabditis elegans. Britton C, et al. Mol Biochem Parasitol, 1999 Oct 15. PMID 10551361
    2. Two oligopeptide transporters from Caenorhabditis elegans: molecular cloning and functional expression. Fei YJ, et al. Biochem J, 1998 Jun 1. PMID 9601088, Free PMC Article
    3. Engineering the Genetic Code in Cells and Animals: Biological Considerations and Impacts. Wang L. Acc Chem Res, 2017 Nov 21. PMID 28984438, Free PMC Article
    4. A novel H(+)-coupled oligopeptide transporter (OPT3) from Caenorhabditis elegans with a predominant function as a H(+) channel and an exclusive expression in neurons. Fei YJ, et al. J Biol Chem, 2000 Mar 31. PMID 10734106
    5. Maintenance of the intestinal tube in Caenorhabditis elegans: the role of the intermediate filament protein IFC-2. Hüsken K, et al. Differentiation, 2008 Oct. PMID 18452552

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dipeptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oligopeptide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in dipeptide import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligopeptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Peptide transporter family 2
    NP_502002.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10790653..10794559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069601.5 → NP_502002.1  Peptide transporter family 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502002.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76185, Q17758
      Conserved Domains (3) summary
      TIGR00926
      Location:46 → 759
      2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)
      pfam00854
      Location:99 → 494
      PTR2; POT family
      cl21472
      Location:666 → 721
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17758.2

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