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    dnj-25 J domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180356, updated on 2-Nov-2024

    Summary

    Official Symbol
    dnj-25
    Official Full Name
    J domain-containing protein
    Primary source
    WormBase:WBGene00001043
    Locus tag
    CELE_W07A8.3
    See related
    AllianceGenome:WB:WBGene00001043
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable clathrin binding activity. Involved in receptor-mediated endocytosis. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Is expressed in hypodermis and pharynx. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 19A. Orthologous to several human genes including DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See dnj-25 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    17
    Sequence:
    Chromosome: V; NC_003283.11 (20729948..20744346, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene F-box C protein Neighboring gene Phospholipase A(2);phospholipase A2 Neighboring gene F-box associated domain-containing protein Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene pseudo Neighboring gene Serpentine Receptor, class T Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Defective pharyngeal development protein 4 Neighboring gene ncRNA

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in clathrin coat disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    J domain-containing protein
    NP_001256947.1
    • Confirmed by transcript evidence
    NP_001256948.1
    • Confirmed by transcript evidence
    NP_001256949.1
    • Confirmed by transcript evidence
    NP_001360578.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20729948..20744346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373209.3NP_001360578.1  J domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WXP9
      Conserved Domains (2) summary
      smart00271
      Location:735782
      DnaJ; DnaJ molecular chaperone homology domain
      pfam05109
      Location:466660
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    2. NM_001270020.4NP_001256949.1  J domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256949.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D7SFQ6
      Conserved Domains (2) summary
      smart00271
      Location:390437
      DnaJ; DnaJ molecular chaperone homology domain
      pfam05109
      Location:123315
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    3. NM_001270018.3NP_001256947.1  J domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256947.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDJ6
      Conserved Domains (2) summary
      smart00271
      Location:733780
      DnaJ; DnaJ molecular chaperone homology domain
      pfam05109
      Location:466658
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    4. NM_001270019.3NP_001256948.1  J domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256948.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D7SFQ5
      Conserved Domains (2) summary
      smart00271
      Location:407454
      DnaJ; DnaJ molecular chaperone homology domain
      pfam05109
      Location:140332
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)