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    rep-1 Rab proteins geranylgeranyltransferase component A 1 [ Caenorhabditis elegans ]

    Gene ID: 175311, updated on 9-Dec-2024

    Summary

    Official Symbol
    rep-1
    Official Full Name
    Rab proteins geranylgeranyltransferase component A 1
    Primary source
    WormBase:WBGene00022051
    Locus tag
    CELE_Y67D2.1
    See related
    AllianceGenome:WB:WBGene00022051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity and Rab GDP-dissociation inhibitor activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in cytoplasm. Predicted to be part of Rab-protein geranylgeranyltransferase complex. Predicted to be active in cytosol and nucleus. Is expressed in alimentary muscle; body wall musculature; hypodermis; and neurons. Human ortholog(s) of this gene implicated in asthma and choroideremia. Orthologous to human CHM (CHM Rab escort protein) and CHML (CHM like Rab escort protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See rep-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (1570306..1576638)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Early ELOngation arrest Neighboring gene ncRNA Neighboring gene Ubiquitin carboxyl-terminal hydrolase Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene Talin_middle domain-containing protein Neighboring gene tRNA

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in intracellular protein transport  
    involved_in protein geranylgeranylation  
    involved_in protein transport  
    involved_in small GTPase-mediated signal transduction  
    involved_in vesicle-mediated transport  
    Component Evidence Code Pubs
    part_of Rab-protein geranylgeranyltransferase complex  
    part_of Rab-protein geranylgeranyltransferase complex  
    located_in cytoplasm  
    is_active_in cytosol  
    is_active_in nucleus  

    General protein information

    Preferred Names
    Rab proteins geranylgeranyltransferase component A 1
    NP_001022928.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      1570306..1576638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027757.6 → NP_001022928.1  Rab proteins geranylgeranyltransferase component A 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022928.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9BKQ5
      Conserved Domains (1) summary
      cl21454
      Location:1 → 361
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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