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    hex-1 Beta-hexosaminidase A [ Caenorhabditis elegans ]

    Gene ID: 180533, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hex-1
    Official Full Name
    Beta-hexosaminidase A
    Primary source
    WormBase:WBGene00020509
    Locus tag
    CELE_T14F9.3
    See related
    AllianceGenome:WB:WBGene00020509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables beta-N-acetylhexosaminidase activity. Involved in carbohydrate metabolic process. Predicted to be active in lysosome and membrane. Is expressed in body wall musculature; coelomocyte; head mesodermal cell; nervous system; and pharynx. Human ortholog(s) of this gene implicated in Sandhoff disease; Tay-Sachs disease; and spinal muscular atrophy. Orthologous to human HEXA (hexosaminidase subunit alpha) and HEXB (hexosaminidase subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hex-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (2223484..2226620)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene FLYWCH-type zinc finger-containing protein peb-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Asp

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables beta-N-acetylhexosaminidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-N-acetylhexosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-N-acetylhexosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycosaminoglycan metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Beta-hexosaminidase A
    NP_508409.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2223484..2226620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076008.8 → NP_508409.1  Beta-hexosaminidase A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508409.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7DY65, Q22492
      Conserved Domains (2) summary
      cd06562
      Location:170 → 529
      GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...
      cl03741
      Location:99 → 147
      Glyco_hydro_20b; Glycosyl hydrolase family 20, domain 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22492.1

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