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    enpl-1 Endoplasmin homolog [ Caenorhabditis elegans ]

    Gene ID: 178014, updated on 2-Nov-2024

    Summary

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    Official Symbol
    enpl-1
    Official Full Name
    Endoplasmin homolog
    Primary source
    WormBase:WBGene00011480
    Locus tag
    CELE_T05E11.3
    See related
    AllianceGenome:WB:WBGene00011480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity; ATP hydrolysis activity; and unfolded protein binding activity. Predicted to be involved in ERAD pathway and protein folding. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum and perinuclear region of cytoplasm. Is expressed in several structures, including germ line; head; intestine; pharynx; and vulva. Used to study cardiovascular system disease. Orthologous to human HSP90B1 (heat shock protein 90 beta family member 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See enpl-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (11119298..11123155)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene CLaudin-like in Caenorhabditis Neighboring gene Intramembrane protease 2 Neighboring gene DNA topoisomerase (ATP-hydrolyzing);Meiotic recombination protein spo-11 Neighboring gene SWI/SNF chromatin remodeling complex core catalytic subunit swsn-4 Neighboring gene 3-hydroxyacyl-CoA dehydrogenase;3-hydroxyacyl-CoA dehydrogenase type-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ENPL-1, the Caenorhabditis elegans homolog of GRP94, promotes insulin secretion via regulation of proinsulin processing and maturation. Podraza-Farhanieh A, et al. Development, 2020 Oct 27. PMID 33037039, Free PMC Article
    2. Proteomics analysis in Caenorhabditis elegans to elucidate the response induced by tyrosol, an olive phenol that stimulates longevity and stress resistance. Cañuelo A, et al. Proteomics, 2013 Oct. PMID 23929540
    3. Depletion of the ER chaperone ENPL-1 sensitizes C. elegans to the anticancer drug cisplatin. Natarajan B, et al. Worm, 2013 Jan 1. PMID 24058864, Free PMC Article
    4. A proinsulin-dependent interaction between ENPL-1 and ASNA-1 in neurons is required to maintain insulin secretion in C. elegans. Podraza-Farhanieh A, et al. Development, 2023 Mar 15. PMID 36939052, Free PMC Article
    5. Expression of hepatitis B virus surface antigens induces defective gonad phenotypes in Caenorhabditis elegans. Chen YY, et al. World J Virol, 2017 Feb 12. PMID 28239568, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A proinsulin-dependent interaction between ENPL-1 and ASNA-1 in neurons is required to maintain insulin secretion in C. elegans.
      Title: A proinsulin-dependent interaction between ENPL-1 and ASNA-1 in neurons is required to maintain insulin secretion in C. elegans.
    2. ENPL-1, the Caenorhabditis elegans homolog of GRP94, promotes insulin secretion via regulation of proinsulin processing and maturation.
      Title: ENPL-1, the Caenorhabditis elegans homolog of GRP94, promotes insulin secretion via regulation of proinsulin processing and maturation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Endoplasmin homolog
    NP_001255536.1
    • Confirmed by transcript evidence
    NP_001255537.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11119298..11123155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268607.4 → NP_001255536.1  Endoplasmin homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255536.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E9P859, Q22235
      Conserved Domains (3) summary
      smart00387
      Location:84 → 242
      HATPase_c; Histidine kinase-like ATPases
      PRK05218
      Location:59 → 724
      PRK05218; heat shock protein 90; Provisional
      pfam00183
      Location:245 → 735
      HSP90; Hsp90 protein

    2. NM_001268608.3 → NP_001255537.1  Endoplasmin homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255537.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22235
      Conserved Domains (3) summary
      smart00387
      Location:12 → 170
      HATPase_c; Histidine kinase-like ATPases
      PRK05218
      Location:4 → 652
      PRK05218; heat shock protein 90; Provisional
      pfam00183
      Location:173 → 663
      HSP90; Hsp90 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22235.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.