rab-8 Ras-related protein Rab-8A [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rab-8
Official Full Name: Ras-related protein Rab-8A
Primary source: WormBase:WBGene00004272
Locus tag: CELE_D1037.4
See related: AllianceGenome:WB:WBGene00004272
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GTPase activating protein binding activity and ankyrin repeat binding activity. Involved in several processes, including embryonic genitalia morphogenesis; negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and protein secretion. Located in apical cortex; apical plasma membrane; and cytoplasmic vesicle. Is expressed in body wall musculature and intestine. Orthologous to several human genes including RAB8B (RAB8B, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rab-8 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (3682890..3684086, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coordination of RAB-8 and RAB-11 during unconventional protein secretion.
Title: Coordination of RAB-8 and RAB-11 during unconventional protein secretion.
SMGL-1/NBAS acts as a RAB-8 GEF to regulate unconventional protein secretion.
Title: SMGL-1/NBAS acts as a RAB-8 GEF to regulate unconventional protein secretion.
Data show that elipsa encodes a coiled-coil polypeptide that localizes to cilia, and that it interacts genetically with Rabaptin5, a well-studied regulator of endocytosis, which in turn interacts with Rab8, a small GTPase, known to localize to cilia.
Title: Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1037.1 (e-PCR)
- UniSTS:317355

D1037.4 (e-PCR)
- UniSTS:317357

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activating protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ankyrin repeat binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in embryonic genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in transport vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Ras-related protein Rab-8A

NP_491199.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

3682890..3684086 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058798.9 → NP_491199.2 Ras-related protein Rab-8A [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491199.2

Status: REVIEWED

UniProtKB/TrEMBL

G5EFC1, I7F493

Conserved Domains (2) summary

smart00175
Location:9 → 172

RAB; Rab subfamily of small GTPases

cd01867
Location:6 → 172

Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)