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    W02F12.4 Exonuclease domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179062, updated on 2-Nov-2024

    Summary

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    Official Symbol
    W02F12.4
    Official Full Name
    Exonuclease domain-containing protein
    Primary source
    WormBase:WBGene00020949
    Locus tag
    CELE_W02F12.4
    See related
    AllianceGenome:WB:WBGene00020949
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3'-5'-DNA exonuclease activity. Predicted to be involved in DNA catabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; retinal vasculopathy with cerebral leukodystrophy; and systemic lupus erythematosus. Orthologous to human TREX1 (three prime repair exonuclease 1) and TREX2 (three prime repair exonuclease 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See W02F12.4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (6704549..6706934, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Alkaline ceramidase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Embryonic mRna (mRNA) Anterior Neighboring gene Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3'-5'-DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Exonuclease domain-containing protein
    NP_001024182.2
    • Confirmed by transcript evidence
    NP_001024183.2
    • Confirmed by transcript evidence
    NP_001024184.2
    • Confirmed by transcript evidence
    NP_001256068.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6704549..6706934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029013.4 → NP_001024184.2  Exonuclease domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024184.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7E2K4

    2. NM_001029012.4 → NP_001024183.2  Exonuclease domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024183.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0G0

    3. NM_001029011.6 → NP_001024182.2  Exonuclease domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024182.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0F9

    4. NM_001269139.2 → NP_001256068.1  Exonuclease domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256068.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1ZUX4
      Conserved Domains (1) summary
      cl10012
      Location:59 → 265
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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