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    nhr-11 NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-11 [ Caenorhabditis elegans ]

    Gene ID: 177724, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nhr-11
    Official Full Name
    NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-11
    Primary source
    WormBase:WBGene00003610
    Locus tag
    CELE_ZC410.1
    See related
    AllianceGenome:WB:WBGene00003610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in body wall; head ganglion; and head neurons. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See nhr-11 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (9070003..9073622)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Mitochondrial-processing peptidase subunit beta Neighboring gene alpha-1,2-Mannosidase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coordinate regulation of lipid metabolism by novel nuclear receptor partnerships. Pathare PP, et al. PLoS Genet, 2012. PMID 22511885, Free PMC Article
    2. Differential expression of genes in C. elegans reveals transcriptional responses to indirect-acting xenobiotic compounds and insensitivity to 2,3,7,8-tetrachlorodibenzodioxin. Karengera A, et al. Ecotoxicol Environ Saf, 2022 Mar 15. PMID 35219257
    3. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    4. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-11
    NP_001041063.1
    • Confirmed by transcript evidence
    NP_001041064.2
    • Confirmed by transcript evidence
    NP_001255359.1
    • Confirmed by transcript evidence
    NP_001255360.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9070003..9073622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268430.4 → NP_001255359.1  Nuclear hormone receptor family member nhr-11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255359.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2T1
      Conserved Domains (2) summary
      smart00399
      Location:4 → 74
      ZnF_C4; c4 zinc finger in nuclear hormone receptors
      smart00430
      Location:244 → 423
      HOLI; Ligand binding domain of hormone receptors

    2. NM_001047598.3 → NP_001041063.1  Nuclear hormone receptor family member nhr-11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041063.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1NZ29, Q23294
      UniProtKB/TrEMBL
      Q5VKT4
      Conserved Domains (2) summary
      smart00399
      Location:4 → 77
      ZnF_C4; c4 zinc finger in nuclear hormone receptors
      smart00430
      Location:247 → 426
      HOLI; Ligand binding domain of hormone receptors

    3. NM_001047599.4 → NP_001041064.2  Nuclear hormone receptor family member nhr-11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041064.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23294
      Conserved Domains (1) summary
      smart00430
      Location:130 → 309
      HOLI; Ligand binding domain of hormone receptors

    4. NM_001268431.3 → NP_001255360.1  NR LBD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255360.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2T0
      Conserved Domains (1) summary
      smart00430
      Location:65 → 244
      HOLI; Ligand binding domain of hormone receptors

    RNA

    1. NR_003464.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23294.3

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