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    htp-2 HORMA domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177405, updated on 2-Nov-2024

    Summary

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    Official Symbol
    htp-2
    Official Full Name
    HORMA domain-containing protein
    Primary source
    WormBase:WBGene00002033
    Locus tag
    CELE_Y73B6BL.2
    See related
    AllianceGenome:WB:WBGene00002033
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in regulation of centriole-centriole cohesion. Located in lateral element. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See htp-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (6419522..6420898)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Exosome complex component RRP4 homolog Neighboring gene Nitrogen regulatory IIA protein Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene PUM-HD domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crossovers trigger a remodeling of meiotic chromosome axis composition that is linked to two-step loss of sister chromatid cohesion. Martinez-Perez E, et al. Genes Dev, 2008 Oct 15. PMID 18923085, Free PMC Article
    2. Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in Caenorhabditis elegans. Sato-Carlton A, et al. PLoS Genet, 2020 Nov. PMID 33175901, Free PMC Article
    3. TOP-2 is differentially required for the proper maintenance of the cohesin subunit REC-8 on meiotic chromosomes in Caenorhabditis elegans spermatogenesis and oogenesis. Rourke C, et al. Genetics, 2022 Sep 30. PMID 35951744, Free PMC Article
    4. HTP-1 coordinates synaptonemal complex assembly with homolog alignment during meiosis in C. elegans. Couteau F, et al. Genes Dev, 2005 Nov 15. PMID 16291647, Free PMC Article
    5. Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis. Ferrandiz N, et al. Nat Commun, 2018 Feb 26. PMID 29483514, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of centriole-centriole cohesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lateral element IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    HORMA domain-containing protein
    NP_500981.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6419522..6420898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068580.8 → NP_500981.3  HORMA domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500981.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95XC8
      Conserved Domains (1) summary
      pfam02301
      Location:38 → 240
      HORMA; HORMA domain
    Nucleotide Protein
    Heading Accession and Version

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