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    unc-60 Actin-depolymerizing factor 2 [ Caenorhabditis elegans ]

    Gene ID: 178640, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-60
    Official Full Name
    Actin-depolymerizing factor 2
    Primary source
    WormBase:WBGene00006794
    Locus tag
    CELE_C38C3.5
    See related
    AllianceGenome:WB:WBGene00006794
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables actin filament binding activity. Involved in several processes, including actin filament organization; actin filament severing; and positive regulation of actin filament polymerization. Located in striated muscle thin filament. Part of ribonucleoprotein complex. Is expressed in several structures, including germ line; hermaphrodite gonad; nerve ring; oocyte; and vulva. Human ortholog(s) of this gene implicated in nemaline myopathy 7. Orthologous to several human genes including CFL2 (cofilin 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-60 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (1475086..1479576)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene CTLH domain-containing protein Neighboring gene Actin-depolymerizing factor 1 Neighboring gene non-specific serine/threonine protein kinase Neighboring gene Secreted protein;Transmembrane gamma-carboxyglutamic acid protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Essential role of ADF/cofilin for assembly of contractile actin networks in the C. elegans somatic gonad. Ono K, et al. J Cell Sci, 2008 Aug 15. PMID 18653537, Free PMC Article
    2. The C-terminal tail of UNC-60B (actin depolymerizing factor/cofilin) is critical for maintaining its stable association with F-actin and is implicated in the second actin-binding site. Ono S, et al. J Biol Chem, 2001 Feb 23. PMID 11050090
    3. Mapping a telomere using the translocation eT1(III;V) in Caenorhabditis elegans. Adames KA, et al. Genetics, 1998 Nov. PMID 9799258, Free PMC Article
    4. The two Caenorhabditis elegans actin-depolymerizing factor/cofilin proteins differently enhance actin filament severing and depolymerization. Yamashiro S, et al. Biochemistry, 2005 Nov 1. PMID 16245940, Free PMC Article
    5. Specific requirement for two ADF/cofilin isoforms in distinct actin-dependent processes in Caenorhabditis elegans. Ono K, et al. J Cell Sci, 2003 May 15. PMID 12679387

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The invadopodial membrane is a specialized compartment whose recycling to form dynamic, functional invadopodia is dependent on localized F-actin disassembly by unc-60a.
      Title: ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo.
    2. results suggest that an optimal level of actin-filament-severing activity of ADF/cofilin is required for assembly of actin networks in the somatic gonad
      Title: Essential role of ADF/cofilin for assembly of contractile actin networks in the C. elegans somatic gonad.
    3. Data show that UNC-87 competes with ADF/cofilin (unc-60) for binding to actin filaments and inhibits ADF/cofilin-dependent filament severing and depolymerization in vitro.
      Title: UNC-87, a calponin-related protein in C. elegans, antagonizes ADF/cofilin-mediated actin filament dynamics.
    4. These results indicate that cofilin severs the actin filament by a mechanism of allosteric and cooperative destabilization.
      Title: Actin filament severing by cofilin.
    5. UNC-60A and UNC-60B play distinct roles in specific aspects of actin reorganization in vivo
      Title: Specific requirement for two ADF/cofilin isoforms in distinct actin-dependent processes in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin filament depolymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament severing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cellular component biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in skeletal muscle thin filament assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in striated muscle thin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Actin-depolymerizing factor 2
    NP_503427.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1475086..1479576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071026.11 → NP_503427.2  Actin-depolymerizing factor 2, isoform c [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503427.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q07749
      Conserved Domains (1) summary
      cd11286
      Location:3 → 146
      ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07749.1

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