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    • Showing Current items.

    ppm-2 putative protein phosphatase 2C T23F11.1 [ Caenorhabditis elegans ]

    Gene ID: 175610, updated on 2-Nov-2024

    Summary

    Official Symbol
    ppm-2
    Official Full Name
    putative protein phosphatase 2C T23F11.1
    Primary source
    WormBase:WBGene00011953
    Locus tag
    CELE_T23F11.1
    See related
    AllianceGenome:WB:WBGene00011953
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in negative regulation of axon extension and positive regulation of synapse assembly. Located in presynaptic active zone. Is expressed in intestine; muscle cell; neurons; and pharynx. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See ppm-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (4650494..4653886)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Major sperm protein Neighboring gene ncRNA

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of axon extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    putative protein phosphatase 2C T23F11.1
    NP_001369858.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4650494..4653886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001384078.2NP_001369858.1  putative protein phosphatase 2C T23F11.1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49596
      Conserved Domains (1) summary
      cd00143
      Location:22286
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...