T04C9.1 Rho GTPase-activating protein 26;SH3 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: T04C9.1
Official Full Name: Rho GTPase-activating protein 26;SH3 domain-containing protein
Primary source: WormBase:WBGene00020209
Locus tag: CELE_T04C9.1
See related: AllianceGenome:WB:WBGene00020209
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Predicted to be located in cytoplasm. Is expressed in head; intestine; nervous system; and seam cell. Human ortholog(s) of this gene implicated in X-linked mental retardation with cerebellar hypoplasia and distinctive facial appearance; acute myelomonocytic leukemia; and juvenile myelomonocytic leukemia. Orthologous to several human genes including ARHGAP10 (Rho GTPase activating protein 10); ARHGAP26 (Rho GTPase activating protein 26); and ARHGAP42 (Rho GTPase activating protein 42). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See T04C9.1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 17

Sequence:: Chromosome: III; NC_003281.10 (5993213..6006369)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lack of T04C9.1, the Homologue of Mammalian APPL2, Leads to Premature Ageing and Shortens Lifespan in Caenorhabditis elegans.
Title: Lack of T04C9.1, the Homologue of Mammalian APPL2, Leads to Premature Ageing and Shortens Lifespan in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T04C9.1 (e-PCR)
- UniSTS:320130

ZK328.3 (e-PCR)
- UniSTS:310468

T04C9.2 (e-PCR)
- UniSTS:316120

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Rho GTPase-activating protein 26;SH3 domain-containing protein

NP_001293638.1

Partially confirmed by transcript evidence

NP_741163.2

Confirmed by transcript evidence

NP_741164.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5993213..6006369

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171870.4 → NP_741164.2 Rho GTPase-activating protein 26 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741164.2

Status: REVIEWED

UniProtKB/TrEMBL

H2KZV7

Conserved Domains (4) summary

cd07602
Location:19 → 225

BAR_RhoGAP_OPHN1-like; The Bin/Amphiphysin/Rvs (BAR) domain of Oligophrenin1-like Rho GTPase Activating Proteins

cd11882
Location:808 → 861

SH3_GRAF-like; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase and similar proteins

cd01249
Location:271 → 388

BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

cl02570
Location:381 → 585

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
NM_171143.8 → NP_741163.2 Rho GTPase-activating protein 26 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741163.2

Status: REVIEWED

UniProtKB/TrEMBL

H2KZV6

Conserved Domains (4) summary

cd07602
Location:19 → 225

BAR_RhoGAP_OPHN1-like; The Bin/Amphiphysin/Rvs (BAR) domain of Oligophrenin1-like Rho GTPase Activating Proteins

cd11882
Location:826 → 879

SH3_GRAF-like; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase and similar proteins

cd01249
Location:271 → 388

BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

cl02570
Location:381 → 585

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
NM_001306709.3 → NP_001293638.1 SH3 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293638.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MPT2

Conserved Domains (2) summary

cd11882
Location:420 → 473

SH3_GRAF-like; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase and similar proteins

cd04374
Location:40 → 245

RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...