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    spk-1 Serine/threonine-protein kinase spk-1;non-specific serine/threonine protein kinase [ Caenorhabditis elegans ]

    Gene ID: 176328, updated on 2-Nov-2024

    Summary

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    Official Symbol
    spk-1
    Official Full Name
    Serine/threonine-protein kinase spk-1;non-specific serine/threonine protein kinase
    Primary source
    WormBase:WBGene00004980
    Locus tag
    CELE_B0464.5
    See related
    AllianceGenome:WB:WBGene00004980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein serine/threonine kinase activity. Involved in embryo development and protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including hypodermis; intestine; nervous system; pharyngeal-intestinal valve; and reproductive system. Orthologous to human SRPK1 (SRSF protein kinase 1); SRPK2 (SRSF protein kinase 2); and SRPK3 (SRSF protein kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See spk-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (9456608..9463007)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene AH domain-containing protein Neighboring gene GTP-binding protein Rheb homolog 1 Neighboring gene Uncharacterized protein Neighboring gene putative protein phosphatase methylesterase 1 Neighboring gene Barrier-to-autointegration factor 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SPK-1, an SR protein kinase, inhibits programmed cell death in Caenorhabditis elegans. Galvin BD, et al. Proc Natl Acad Sci U S A, 2011 Feb 1. PMID 21245325, Free PMC Article
    2. Alternative 3' UTR selection controls PAR-5 homeostasis and cell polarity in C. elegans embryos. Mikl M, et al. Cell Rep, 2014 Sep 11. PMID 25199833
    3. SPK-1, a C. elegans SR protein kinase homologue, is essential for embryogenesis and required for germline development. Kuroyanagi H, et al. Mech Dev, 2000 Dec. PMID 11091073
    4. Lamin regulates the dietary restriction response via the mTOR pathway in Caenorhabditis elegans. Charar C, et al. J Cell Sci, 2021 Sep 1. PMID 34383046, Free PMC Article
    5. Functional characterization of SR and SR-related genes in Caenorhabditis elegans. Longman D, et al. EMBO J, 2000 Apr 3. PMID 10747030, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein kinase spk-1;non-specific serine/threonine protein kinase
    NP_001021133.1
    • Confirmed by transcript evidence
    NP_001021134.1
    • Partially confirmed by transcript evidence
    NP_001293645.1
    • Confirmed by transcript evidence
    NP_499080.3
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9456608..9463007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025963.6 → NP_001021134.1  Serine/threonine-protein kinase spk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021134.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03563
      Conserved Domains (2) summary
      smart00220
      Location:134 → 284
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:123 → 675
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001025962.3 → NP_001021133.1  Serine/threonine-protein kinase spk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021133.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03563
      Conserved Domains (2) summary
      smart00220
      Location:134 → 616
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14136
      Location:123 → 616
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase

    3. NM_066679.5 → NP_499080.3  Serine/threonine-protein kinase spk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499080.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03563, Q9XVX9, Q9XVY0
      Conserved Domains (2) summary
      smart00220
      Location:422 → 904
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14136
      Location:411 → 904
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase

    4. NM_001306716.3 → NP_001293645.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293645.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M1ZJY1
      Conserved Domains (1) summary
      cd14136
      Location:27 → 520
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03563.3

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