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    BZZ1 Bzz1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856514, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BZZ1
    Official Full Name
    Bzz1p
    Primary source
    SGD:S000001156
    Locus tag
    YHR114W
    See related
    AllianceGenome:SGD:S000001156; FungiDB:YHR114W; VEuPathDB:YHR114W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LSB7
    Summary
    Enables enzyme activator activity and phospholipid binding activity. Involved in actin nucleation; endocytosis; and response to salt stress. Located in actin cortical patch and plasma membrane. Orthologous to several human genes including FNBP1L (formin binding protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BZZ1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (338083..339984)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene putative cystathionine beta-lyase Neighboring gene aspartyl aminopeptidase Neighboring gene ubiquitin-conjugating protein DMA1 Neighboring gene Cox23p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The WASP/Las17p-interacting protein Bzz1p functions with Myo5p in an early stage of endocytosis. Soulard A, et al. Protoplasma, 2005 Oct. PMID 16231105
    2. Control of lipid organization and actin assembly during clathrin-mediated endocytosis by the cytoplasmic tail of the rhomboid protein Rbd2. Cortesio CL, et al. Mol Biol Cell, 2015 Apr 15. PMID 25694450, Free PMC Article
    3. Membrane-sculpting BAR domains generate stable lipid microdomains. Zhao H, et al. Cell Rep, 2013 Sep 26. PMID 24055060, Free PMC Article
    4. Global genetic determinants of mitochondrial DNA copy number. Zhang H, et al. PLoS One, 2014. PMID 25170845, Free PMC Article
    5. Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro. Soulard A, et al. Mol Cell Biol, 2002 Nov. PMID 12391157, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The syndapin-like F-BAR protein Bzz1 functions in a pathway with Rbd2 to control the timing of type 1 myosin recruitment and actin polymerization onset during clathrin-mediated endocytosis.
      Title: Control of lipid organization and actin assembly during clathrin-mediated endocytosis by the cytoplasmic tail of the rhomboid protein Rbd2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament organization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in actin nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to salt stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to salt stress IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck HDA PubMed 
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mating projection tip HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Bzz1p
    NP_011982.1
    • SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      338083..339984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179244.1 → NP_011982.1  TPA: Bzz1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011982.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL64, E9P8V2, P38822
      UniProtKB/TrEMBL
      B3LSM9, N1P9F2
      Conserved Domains (3) summary
      cd11777
      Location:497 → 552
      SH3_CIP4_Bzz1_like; Src Homology 3 domain of Cdc42-Interacting Protein 4, Bzz1 and similar domains
      cd11778
      Location:581 → 631
      SH3_Bzz1_2; Second Src Homology 3 domain of Bzz1 and similar domains
      cl12013
      Location:10 → 256
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38822.1

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