gldi-2 EGF-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gldi-2
Official Full Name: EGF-like domain-containing protein
Primary source: WormBase:WBGene00020481
Locus tag: CELE_T13C2.6
See related: AllianceGenome:WB:WBGene00020481
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in endocytosis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LRP8 (LDL receptor related protein 8); LDLR (low density lipoprotein receptor); and VLDLR (very low density lipoprotein receptor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gldi-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 13

Sequence:: Chromosome: II; NC_003280.10 (6783427..6788270)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T13C2.4 (e-PCR)
- UniSTS:310832

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endocytosis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: EGF-like domain-containing protein

NP_001408275.1

Confirmed by transcript evidence

NP_001408276.1

Confirmed by transcript evidence

NP_495387.2

Confirmed by transcript evidence

NP_872023.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6783427..6788270

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062986.6 → NP_495387.2 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495387.2

Status: REVIEWED

UniProtKB/TrEMBL

H2KZX4

Conserved Domains (4) summary

smart00192
Location:165 → 197

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:604 → 647

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:431 → 461

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:212 → 247

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
NM_182223.6 → NP_872023.2 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_872023.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7JP80

Conserved Domains (4) summary

smart00192
Location:167 → 199

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:606 → 649

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:433 → 463

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:214 → 249

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
NM_001421348.1 → NP_001408275.1 EGF-like domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED
NM_001421349.1 → NP_001408276.1 EGF-like domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED