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    gly-6 Ricin B lectin domain-containing protein;putative N-acetylgalactosaminyltransferase 6 [ Caenorhabditis elegans ]

    Gene ID: 175558, updated on 2-Nov-2024

    Summary

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    Official Symbol
    gly-6
    Official Full Name
    Ricin B lectin domain-containing protein;putative N-acetylgalactosaminyltransferase 6
    Primary source
    WormBase:WBGene00001631
    Locus tag
    CELE_H38K22.5
    See related
    AllianceGenome:WB:WBGene00001631
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See gly-6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (4324280..4327987, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene TMhelix containing protein Neighboring gene Cyclin-dependent kinase 12 Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans. Hagen FK, et al. J Biol Chem, 1998 Apr 3. PMID 9525933
    2. The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation. Wang H, et al. Mol Biol Cell, 2005 Sep. PMID 15987734, Free PMC Article
    3. Alternative chaperone machinery may compensate for calreticulin/calnexin deficiency in Caenorhabditis elegans. Lee W, et al. Proteomics, 2006 Feb. PMID 16404716
    4. Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila. Schwientek T, et al. J Biol Chem, 2002 Jun 21. PMID 11925450
    5. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ricin B lectin domain-containing protein;putative N-acetylgalactosaminyltransferase 6
    NP_001022644.1
    • Confirmed by transcript evidence
    NP_001022646.1
    • Confirmed by transcript evidence
    NP_001254913.1
    • Confirmed by transcript evidence
    NP_001370116.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4324280..4327987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027473.5 → NP_001022644.1  putative N-acetylgalactosaminyltransferase 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022644.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61394, O61395, O61396
      Conserved Domains (4) summary
      cd02510
      Location:160 → 463
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:155 → 451
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:476 → 608
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:474 → 606
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. NM_001267984.4 → NP_001254913.1  Ricin B lectin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254913.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0Z3L2
      Conserved Domains (1) summary
      pfam00652
      Location:4 → 129
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    3. NM_001384070.2 → NP_001370116.1  putative N-acetylgalactosaminyltransferase 6 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd02510
      Location:160 → 463
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:477 → 605
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    4. NM_001027475.3 → NP_001022646.1  putative N-acetylgalactosaminyltransferase 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022646.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61394
      Conserved Domains (1) summary
      cd02510
      Location:160 → 463
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O61394.1

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