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    C53B4.3 Major facilitator superfamily (MFS) profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177714, updated on 2-Nov-2024

    Summary

    Official Symbol
    C53B4.3
    Official Full Name
    Major facilitator superfamily (MFS) profile domain-containing protein
    Primary source
    WormBase:WBGene00008273
    Locus tag
    CELE_C53B4.3
    See related
    AllianceGenome:WB:WBGene00008273
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Located in nucleus. Used to study cancer. Human ortholog(s) of this gene implicated in breast cancer; esophagus adenocarcinoma; and lung cancer. Orthologous to human SLC22A18 (solute carrier family 22 member 18). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See C53B4.3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (8970869..8973316, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene DUF4776 domain-containing protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene PDZ Domain containing Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene UAA transporter

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus HDA PubMed 

    General protein information

    Preferred Names
    Major facilitator superfamily (MFS) profile domain-containing protein
    NP_501557.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8970869..8973316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069156.5NP_501557.2  Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501557.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18797
      Conserved Domains (1) summary
      cd17331
      Location:19401
      MFS_SLC22A18; Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters