wbp-2 GRAM domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: wbp-2
Official Full Name: GRAM domain-containing protein
Primary source: WormBase:WBGene00008404
Locus tag: CELE_D2013.6
See related: AllianceGenome:WB:WBGene00008404
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable chromatin DNA binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 107. Orthologous to several human genes including WBP2 (WW domain binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See wbp-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 3

Sequence:: Chromosome: II; NC_003280.10 (9329774..9331527)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2013.6 (e-PCR)
- UniSTS:313971

D2013.5 (e-PCR)
- UniSTS:307401

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GRAM domain-containing protein

NP_495987.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9329774..9331527

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063586.3 → NP_495987.1 GRAM domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495987.1

Status: REVIEWED

UniProtKB/TrEMBL

Q18966

Conserved Domains (1) summary

cd13214
Location:29 → 130

PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain