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    gob-1 Trehalose-phosphatase [ Caenorhabditis elegans ]

    Gene ID: 181637, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gob-1
    Official Full Name
    Trehalose-phosphatase
    Primary source
    WormBase:WBGene00001649
    Locus tag
    CELE_H13N06.3
    See related
    AllianceGenome:WB:WBGene00001649
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables trehalose-phosphatase activity. Involved in carbohydrate derivative catabolic process; dephosphorylation; and trehalose biosynthetic process. Located in cytoplasm. Is expressed in several structures, including body wall musculature; head neurons; intestine; pharynx; and tail. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gob-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (15493602..15497504)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene VWFA domain-containing protein Neighboring gene Cytochrome b5 heme-binding domain-containing protein;sulfite oxidase Neighboring gene DOMON domain-containing protein;Tyramine beta-hydroxylase Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugs. Farelli JD, et al. PLoS Pathog, 2014 Jul. PMID 24992307, Free PMC Article
    2. The C. elegans lethal gut-obstructed gob-1 gene is trehalose-6-phosphate phosphatase. Kormish JD, et al. Dev Biol, 2005 Nov 1. PMID 16197937
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables trehalose-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables trehalose-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate derivative catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in trehalose biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Trehalose-phosphatase
    NP_510560.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15493602..15497504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078159.5 → NP_510560.2  Trehalose-phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510560.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95QD8, Q9XTQ5
      Conserved Domains (1) summary
      pfam18572
      Location:15 → 112
      T6PP_N; Trehalose-6-phosphate phosphatase N-terminal helical bundle domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XTQ5.2

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