vps-32.1 Charged multivesicular body protein 4b [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: vps-32.1
Official Full Name: Charged multivesicular body protein 4b
Primary source: WormBase:WBGene00016961
Locus tag: CELE_C56C10.3
See related: AllianceGenome:WB:WBGene00016961
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and vesicle budding from membrane. Located in endosome membrane. Is expressed in several structures, including coelomocyte; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in cataract 31 multiple types. Orthologous to several human genes including CHMP4B (charged multivesicular body protein 4B) and CHMP4BP1 (charged multivesicular body protein 4B pseudogene 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vps-32.1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (6589708..6591084)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

characterization of CeVPS-32 & its interactions with CeVPS-27, CeVPS-23 & CeVPS-4; CeVPS-32 & CeVPS-27/Hrs are enriched in distinct subdomains at the endosomal membrane
Title: The ESCRT-III protein CeVPS-32 is enriched in domains distinct from CeVPS-27 and CeVPS-23 at the endosomal membrane of epithelial cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C56C10.3 (e-PCR)
- UniSTS:316448

C56C10.8 (e-PCR)
- UniSTS:316450

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in late endosome to vacuole transport via multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in vacuolar transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle budding from membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ESCRT III complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	HDA more info	PubMed
is_active_in multivesicular body	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Charged multivesicular body protein 4b

NP_001370608.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6589708..6591084

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383868.2 → NP_001370608.1 Charged multivesicular body protein 4b [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q18886

Conserved Domains (1) summary

pfam03357
Location:21 → 194

Snf7