drh-1 Helicase ATP-binding domain-containing protein;RNA helicase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: drh-1
Official Full Name: Helicase ATP-binding domain-containing protein;RNA helicase
Primary source: WormBase:WBGene00001090
Locus tag: CELE_F15B10.2
See related: AllianceGenome:WB:WBGene00001090
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP binding activity; helicase activity; and nucleic acid binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and primary immunodeficiency disease. Orthologous to several human genes including RIGI (RNA sensor RIG-I). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See drh-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 20

Sequence:: Chromosome: IV; NC_003282.8 (6607376..6613353, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_003282.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caenorhabditis elegans RIG-I-like receptor DRH-1 signals via CARDs to activate antiviral immunity in intestinal cells.
Title: Caenorhabditis elegans RIG-I-like receptor DRH-1 signals via CARDs to activate antiviral immunity in intestinal cells.
Purification and Characterization of Double-Stranded Nucleic Acid-Dependent ATPase Activities of Tagged Dicer-Related Helicase 1 and its Short Isoform in Caenorhabditis elegans.
Title: Purification and Characterization of Double-Stranded Nucleic Acid-Dependent ATPase Activities of Tagged Dicer-Related Helicase 1 and its Short Isoform in Caenorhabditis elegans.
C. elegans RIG-I homolog DRH-1 mediates the induction of the intracellular pathogen response (IPR), a novel transcriptional defense program, in response to infection by the natural C. elegans viral pathogen Orsay virus.
Title: The Caenorhabditis elegans RIG-I Homolog DRH-1 Mediates the Intracellular Pathogen Response upon Viral Infection.
As RIG-I translocates on long double-stranded RNA (dsRNA) and DRH-1 exists in a complex with Dicer, the authors propose that DRH-1 facilitates the biogenesis of viral small interfering RNAs in nematodes by catalyzing translocation of the Dicer complex on the viral long dsRNA precursors.
Title: Caenorhabditis elegans RIG-I Homolog Mediates Antiviral RNA Interference Downstream of Dicer-Dependent Biogenesis of Viral Small Interfering RNAs.
DRH-1 contributes to antiviral RNA interference by acting as a virus sensor.
Title: Homologous RIG-I-like helicase proteins direct RNAi-mediated antiviral immunity in C. elegans by distinct mechanisms.
LIN28 can directly inhibit let-7g biogenesis at the Dicer processing step
Title: A LIN28-dependent structural change in pre-let-7g directly inhibits dicer processing.
genetic epistatic analysis shows that drh-1 acts downstream of virus sensing and viral siRNA biogenesis to mediate specific antiviral RNAi
Title: An RIG-I-Like RNA helicase mediates antiviral RNAi downstream of viral siRNA biogenesis in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F15B10.2 (e-PCR)
- UniSTS:309773

C01B10.1 (e-PCR)
- UniSTS:308406

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Helicase ATP-binding domain-containing protein;RNA helicase

NP_001368373.1

Confirmed by transcript evidence

NP_501018.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6607376..6613353 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068617.8 → NP_501018.1 RNA helicase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501018.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EDI8

Conserved Domains (5) summary

COG1111
Location:294 → 884

MPH1; ERCC4-related helicase [Replication, recombination and repair]

cd00046
Location:308 → 473

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00271
Location:687 → 809

Helicase_C; Helicase conserved C-terminal domain

cl13152
Location:888 → 1001

RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

cl21459
Location:166 → 227

HTH; Helix-turn-helix domains
NM_001380283.2 → NP_001368373.1 Helicase ATP-binding domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CIX1

Conserved Domains (3) summary

COG1111
Location:36 → 626

MPH1; ERCC4-related helicase [Replication, recombination and repair]

cl13152
Location:629 → 744

RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

cl28899
Location:33 → 245

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily