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    ari-1.1 E3 ubiquitin-protein ligase ari-1.1 [ Caenorhabditis elegans ]

    Gene ID: 172284, updated on 2-Nov-2024

    Summary

    Official Symbol
    ari-1.1
    Official Full Name
    E3 ubiquitin-protein ligase ari-1.1
    Primary source
    WormBase:WBGene00016158
    Locus tag
    CELE_C27A12.8
    See related
    AllianceGenome:WB:WBGene00016158
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including germ line; hermaphrodite gonad; nervous system; non-striated muscle; and rectal gland cell. Orthologous to human ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See ari-1.1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (6058548..6060953, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RBR-type E3 ubiquitin transferase Neighboring gene miscRNA Neighboring gene RBR-type E3 ubiquitin transferase Neighboring gene GPI ethanolamine phosphate transferase 3 Neighboring gene Methyl-CpG binding protein 2/3 C-terminal domain-containing protein Neighboring gene Histone H1

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase ari-1.1
    NP_491749.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6058548..6060953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059348.7NP_491749.2  E3 ubiquitin-protein ligase ari-1.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491749.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01965
      Conserved Domains (4) summary
      smart00647
      Location:196255
      IBR; In Between Ring fingers
      cd00162
      Location:128174
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam01485
      Location:276317
      IBR; IBR domain, a half RING-finger domain
      cl17238
      Location:127180
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain