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    lys-7 Lysozyme-like protein 7 [ Caenorhabditis elegans ]

    Gene ID: 178772, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lys-7
    Official Full Name
    Lysozyme-like protein 7
    Primary source
    WormBase:WBGene00003096
    Locus tag
    CELE_C02A12.4
    See related
    AllianceGenome:WB:WBGene00003096
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in defense response to other organism. Is expressed in head neurons; intestine; and rectal gland cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lys-7 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (3481432..3482600, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class BC (Class B-like) Neighboring gene Serpentine Receptor, class BC (Class B-like) Neighboring gene Serpentine Receptor, class BC (Class B-like) Neighboring gene Serpentine Receptor, class BC (Class B-like)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Black sea cucumber (Holothuria atra Jaeger, 1833) rescues Pseudomonas aeruginosa-infected Caenorhabditis elegans via reduction of pathogen virulence factors and enhancement of host immunity. Lee WT, et al. Food Funct, 2019 Sep 1. PMID 31453615
    2. A Marine Actinomycete Rescues Caenorhabditis elegans from Pseudomonas aeruginosa Infection through Restitution of Lysozyme 7. Fatin SN, et al. Front Microbiol, 2017. PMID 29201023, Free PMC Article
    3. Swietenia macrophylla extract promotes the ability of Caenorhabditis elegans to survive Pseudomonas aeruginosa infection. Dharmalingam K, et al. J Ethnopharmacol, 2012 Jan 31. PMID 22193176
    4. Establishment of a Caenorhabditis elegans infection model for Vibrio alginolyticus. Durai S, et al. J Basic Microbiol, 2011 Jun. PMID 21298688
    5. Chronic exposure to di(2-ethylhexyl) phthalate (DEHP) weakens innate immunity and leads to immunosenescence in C. elegans. Yen PL, et al. Environ Toxicol Pharmacol, 2023 Mar. PMID 36690191

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Lysozyme-like protein 7
    NP_503972.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      3481432..3482600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071571.9 → NP_503972.1  Lysozyme-like protein 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503972.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16202
      Conserved Domains (1) summary
      cd06416
      Location:54 → 256
      GH25_Lys1-like; Lys-1 is a lysozyme encoded by the Caenorhabditis elegans lys-1 gene. This gene is one of a several lysozyme genes upregulated upon infection by the Gram-negative bacterial pathogen Serratia marcescens. Lys-1 contains a glycosyl hydrolase family 25 ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16202.1

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