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    ints-5 Integrator complex subunit 5 [ Caenorhabditis elegans ]

    Gene ID: 180207, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ints-5
    Official Full Name
    Integrator complex subunit 5
    Primary source
    WormBase:WBGene00013075
    Locus tag
    CELE_Y51A2D.7
    See related
    AllianceGenome:WB:WBGene00013075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in snRNA 3'-end processing. Predicted to be part of integrator complex. Orthologous to human INTS5 (integrator complex subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ints-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    15
    Sequence:
    Chromosome: V; NC_003283.11 (18533953..18549101)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Proton myo-inositol cotransporter hmit-1.2 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Cysteine proteinase Neighboring gene DUF4150 domain-containing protein;TransThyretin-Related family domain

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of the Caenorhabditis elegans Integrator complex triggers a non-conventional transcriptional mechanism beyond snRNA genes. Gómez-Orte E, et al. PLoS Genet, 2019 Feb. PMID 30807579, Free PMC Article
    2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    3. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Integrator complex subunit 5
    NP_507625.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      18533953..18549101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075224.6 → NP_507625.2  Integrator complex subunit 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507625.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U267, Q9XXQ8
      Conserved Domains (2) summary
      pfam14837
      Location:43 → 242
      INTS5_N; Integrator complex subunit 5 N-terminus
      pfam14838
      Location:798 → 984
      INTS5_C; Integrator complex subunit 5 C-terminus

    RNA

    1. NR_070171.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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