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    szy-2 Protein phosphatase inhibitor 2 [ Caenorhabditis elegans ]

    Gene ID: 175738, updated on 9-Dec-2024

    Summary

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    Official Symbol
    szy-2
    Official Full Name
    Protein phosphatase inhibitor 2
    Primary source
    WormBase:WBGene00021312
    Locus tag
    CELE_Y32H12A.4
    See related
    AllianceGenome:WB:WBGene00021312
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein phosphatase inhibitor activity. Involved in several processes, including centrosome cycle; chromosome separation; and regulation of centrosome duplication. Orthologous to several human genes including PPP1R2B (PPP1R2 family member B) and PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See szy-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (5368966..5371276, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene Dehydrogenase/reductase SDR family member 1 Neighboring gene Adiponectin receptor protein Neighboring gene Flavodoxin-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation and functions of inhibitor-2 family of proteins. Li M, et al. Biochemistry, 2007 Mar 6. PMID 17286390
    2. Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication. Peel N, et al. PLoS Genet, 2017 Jan. PMID 28103229, Free PMC Article
    3. Suppressors of zyg-1 define regulators of centrosome duplication and nuclear association in Caenorhabditis elegans. Kemp CA, et al. Genetics, 2007 May. PMID 17446307, Free PMC Article
    4. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of centrosome duplication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein phosphatase inhibitor 2
    NP_498147.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5368966..5371276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065746.6 → NP_498147.1  Protein phosphatase inhibitor 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498147.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N537
      Conserved Domains (1) summary
      pfam04979
      Location:52 → 169
      IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
    Nucleotide Protein
    Heading Accession and Version

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