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    npp-19 Nucleoporin NUP35 [ Caenorhabditis elegans ]

    Gene ID: 174663, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npp-19
    Official Full Name
    Nucleoporin NUP35
    Primary source
    WormBase:WBGene00003805
    Locus tag
    CELE_R06F6.5
    See related
    AllianceGenome:WB:WBGene00003805
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phospholipid binding activity. Predicted to be a structural constituent of nuclear pore. Involved in embryo development; nucleus organization; and regulation of exit from mitosis. Located in nuclear envelope. Part of nuclear pore. Is expressed in body wall musculature; nervous system; and pharynx. Orthologous to human NUP35 (nucleoporin 35). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npp-19 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (10796653..10798479, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting-associated protein 11 homolog Neighboring gene SET domain-containing protein 14 Neighboring gene ncRNA Neighboring gene Homeobox protein ceh-62

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nup155 regulates nuclear envelope and nuclear pore complex formation in nematodes and vertebrates. Franz C, et al. EMBO J, 2005 Oct 19. PMID 16193066, Free PMC Article
    2. Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos. Nkombo Nkoula S, et al. Sci Adv, 2023 Jul 21. PMID 37467327, Free PMC Article
    3. Nucleoporins NPP-10, NPP-13 and NPP-20 are required for HCP-4 nuclear import to establish correct centromere assembly. Ferreira J, et al. J Cell Sci, 2017 Mar 1. PMID 28122936
    4. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. D'Angelo MA, et al. Cell, 2009 Jan 23. PMID 19167330, Free PMC Article
    5. Early embryonic requirement for nucleoporin Nup35/NPP-19 in nuclear assembly. Ródenas E, et al. Dev Biol, 2009 Mar 15. PMID 19146848

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear pore organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore nuclear basket IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nucleoporin NUP35
    NP_496324.1
    • Confirmed by transcript evidence
    NP_496325.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10796653..10798479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063923.7 → NP_496324.1  Nucleoporin NUP35 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496324.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62340, Q09601
      Conserved Domains (1) summary
      pfam05172
      Location:195 → 275
      Nup35_RRM; Nup53/35/40-type RNA recognition motif

    2. NM_063924.7 → NP_496325.1  Nucleoporin NUP35 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496325.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09601
      Conserved Domains (1) summary
      pfam05172
      Location:195 → 275
      Nup35_RRM; Nup53/35/40-type RNA recognition motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09601.2

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