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    cutc-1 Copper homeostasis protein cutC homolog [ Caenorhabditis elegans ]

    Gene ID: 176186, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cutc-1
    Official Full Name
    Copper homeostasis protein cutC homolog
    Primary source
    WormBase:WBGene00022702
    Locus tag
    CELE_ZK353.7
    See related
    AllianceGenome:WB:WBGene00022702
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable copper ion binding activity. Involved in several processes, including egg-laying behavior; response to copper ion; and vulval development. Located in cell junction and striated muscle dense body. Orthologous to human CUTC (cutC copper transporter). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See cutc-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003281.10 (8402049..8403607, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Leucine aminopeptidase 1 Neighboring gene UBX domain-containing protein 4 Neighboring gene Cyclin-Y

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Knock down of Caenorhabditis elegans cutc-1 exacerbates the sensitivity toward high levels of copper. Calafato S, et al. Toxicol Sci, 2008 Dec. PMID 18723824
    2. An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans. Meissner B, et al. PLoS Genet, 2009 Jun. PMID 19557190, Free PMC Article
    3. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    4. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organismal reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell junction HDA PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in striated muscle dense body HDA PubMed 

    General protein information

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    Preferred Names
    Copper homeostasis protein cutC homolog
    NP_498855.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8402049..8403607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066454.6 → NP_498855.1  Copper homeostasis protein cutC homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498855.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34630
      Conserved Domains (1) summary
      COG3142
      Location:10 → 248
      CutC; Copper homeostasis protein CutC [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34630.1

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