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    cpg-2 Chondroitin proteoglycan-2 [ Caenorhabditis elegans ]

    Gene ID: 175991, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpg-2
    Official Full Name
    Chondroitin proteoglycan-2
    Primary source
    WormBase:WBGene00015102
    Locus tag
    CELE_B0280.5
    See related
    AllianceGenome:WB:WBGene00015102
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables chitin binding activity. Involved in several processes, including eggshell formation; mitotic cytokinesis; and regulation of cytokinesis. Located in external encapsulating structure and perivitelline space. Is expressed in eggshell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cpg-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (7102092..7103990, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Nuclear hormone receptor family member nhr-9 Neighboring gene NR LBD domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif containing protein required for C. elegans germ cell development. Lee MH, et al. Genes Dev, 2001 Sep 15. PMID 11562350, Free PMC Article
    2. Hierarchical assembly of the eggshell and permeability barrier in C. elegans. Olson SK, et al. J Cell Biol, 2012 Aug 20. PMID 22908315, Free PMC Article
    3. The eggshell is required for meiotic fidelity, polar-body extrusion and polarization of the C. elegans embryo. Johnston WL, et al. BMC Biol, 2006 Oct 16. PMID 17042944, Free PMC Article
    4. Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2. Olson SK, et al. J Cell Biol, 2006 Jun 19. PMID 16785326, Free PMC Article
    5. Cortical granule exocytosis in C. elegans is regulated by cell cycle components including separase. Bembenek JN, et al. Development, 2007 Nov. PMID 17913784, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chondroitin chains on CPG-1 and CPG-2 proteoglycans are required for cytokinesis.
      Title: Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in eggshell formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in eggshell formation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external encapsulating structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perivitelline space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Chondroitin proteoglycan-2
    NP_498551.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7102092..7103990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066150.14 → NP_498551.3  Chondroitin proteoglycan-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498551.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41996, Q1A3T5
      Conserved Domains (2) summary
      smart00494
      Location:245 → 293
      ChtBD2; Chitin-binding domain type 2
      pfam01607
      Location:24 → 76
      CBM_14; Chitin binding Peritrophin-A domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41996.3

    Gene LinkOut

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