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    ace-4 Carboxylic ester hydrolase [ Caenorhabditis elegans ]

    Gene ID: 175074, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ace-4
    Official Full Name
    Carboxylic ester hydrolase
    Primary source
    WormBase:WBGene00000038
    Locus tag
    CELE_Y48B6A.7
    See related
    AllianceGenome:WB:WBGene00000038
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cholinesterase activity. Predicted to be active in extracellular space and plasma membrane. Is expressed in body wall musculature; neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); drug dependence (multiple); myasthenia gravis; and subacute delirium. Orthologous to human ACHE (acetylcholinesterase (Yt blood group)) and BCHE (butyrylcholinesterase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ace-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    17
    Sequence:
    Chromosome: II; NC_003280.10 (14198046..14205460)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Carboxylic ester hydrolase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple ace genes encoding acetylcholinesterases of Caenorhabditis elegans have distinct tissue expression. Combes D, et al. Eur J Neurosci, 2003 Aug. PMID 12911746
    2. Acetylcholinesterase genes in the nematode Caenorhabditis elegans. Combes D, et al. Int Rev Cytol, 2001. PMID 11580201
    3. Four genes encode acetylcholinesterases in the nematodes Caenorhabditis elegans and Caenorhabditis briggsae. cDNA sequences, genomic structures, mutations and in vivo expression. Combes D, et al. J Mol Biol, 2000 Jul 21. PMID 10891266
    4. Mutation of the feh-1 gene, the Caenorhabditis elegans orthologue of mammalian Fe65, decreases the expression of two acetylcholinesterase genes. Bimonte M, et al. Eur J Neurosci, 2004 Sep. PMID 15355315
    5. Misexpression of acetylcholinesterases in the C. elegans pha-2 mutant accompanies ultrastructural defects in pharyngeal muscle cells. Mörck C, et al. Dev Biol, 2006 Sep 15. PMID 16806153

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    NOT enables acetylcholinesterase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cholinesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Carboxylic ester hydrolase
    NP_496962.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14198046..14205460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064561.6 → NP_496962.1  Carboxylic ester hydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496962.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDN1
      Conserved Domains (2) summary
      COG0657
      Location:120 → 243
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:28 → 562
      COesterase; Carboxylesterase family
    Nucleotide Protein
    Heading Accession and Version

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