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    rha-2 Putative ATP-dependent RNA helicase rha-2 [ Caenorhabditis elegans ]

    Gene ID: 176207, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rha-2
    Official Full Name
    Putative ATP-dependent RNA helicase rha-2
    Primary source
    WormBase:WBGene00015525
    Locus tag
    CELE_C06E1.10
    See related
    AllianceGenome:WB:WBGene00015525
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity and helicase activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in 46,XY sex reversal. Orthologous to human DHX37 (DEAH-box helicase 37). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See rha-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (8609882..8614569, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Zinc finger transcription factor family protein 30 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA. Zhu C, et al. Proc Natl Acad Sci U S A, 2018 Oct 2. PMID 30224484, Free PMC Article
    2. C. elegans longevity pathways converge to decrease mitochondrial membrane potential. Lemire BD, et al. Mech Ageing Dev, 2009 Jul. PMID 19442682
    3. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. Hansen M, et al. PLoS Genet, 2005 Jul. PMID 16103914, Free PMC Article
    4. Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development. Arur S, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19264959, Free PMC Article
    5. An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans. Meissner B, et al. PLoS Genet, 2009 Jun. PMID 19557190, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reproductive process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Putative ATP-dependent RNA helicase rha-2
    NP_498895.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8609882..8614569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066494.3 → NP_498895.1  Putative ATP-dependent RNA helicase rha-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498895.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34305
      Conserved Domains (6) summary
      smart00490
      Location:577 → 662
      HELICc; helicase superfamily c-terminal domain
      smart00847
      Location:730 → 822
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:218 → 989
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd00046
      Location:254 → 394
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:870 → 990
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
      cl21455
      Location:350 → 477
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34305.2

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