U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    soc-2 Leucine-rich repeat protein SHOC-2;Leucine-rich repeat protein soc-2 [ Caenorhabditis elegans ]

    Gene ID: 177286, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    soc-2
    Official Full Name
    Leucine-rich repeat protein SHOC-2;Leucine-rich repeat protein soc-2
    Primary source
    WormBase:WBGene00004929
    Locus tag
    CELE_AC7.2
    See related
    AllianceGenome:WB:WBGene00004929
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables small GTPase binding activity. Involved in several processes, including fibroblast growth factor receptor signaling pathway; positive regulation of Ras protein signal transduction; and vulval development. Is expressed in several structures, including hypodermis; intestine; nervous system; reproductive system; and tail. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 1 and atopic dermatitis. Orthologous to human SHOC2 (SHOC2 leucine rich repeat scaffold protein). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See soc-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (5127041..5152491, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transmembrane 9 superfamily member Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. N-Glycosylation regulates fibroblast growth factor receptor/EGL-15 activity in Caenorhabditis elegans in vivo. Polanska UM, et al. J Biol Chem, 2009 Nov 27. PMID 19801543, Free PMC Article
    2. LET-413 is a basolateral protein required for the assembly of adherens junctions in Caenorhabditis elegans. Legouis R, et al. Nat Cell Biol, 2000 Jul. PMID 10878806
    3. Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair. Cordeddu V, et al. Nat Genet, 2009 Sep. PMID 19684605, Free PMC Article
    4. An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites. DeVore DL, et al. Cell, 1995 Nov 17. PMID 7585964
    5. soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling. Selfors LM, et al. Proc Natl Acad Sci U S A, 1998 Jun 9. PMID 9618511, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables volume-sensitive anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell projection organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Leucine-rich repeat protein SHOC-2;Leucine-rich repeat protein soc-2
    NP_001021259.1
    • Confirmed by transcript evidence
    NP_001293758.1
    • Confirmed by transcript evidence
    NP_001293759.1
    • Partially confirmed by transcript evidence
    NP_741391.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5127041..5152491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306829.3 → NP_001293758.1  Leucine-rich repeat protein soc-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293758.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CJ50
      Conserved Domains (2) summary
      PLN00113
      Location:150 → 605
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:148 → 169
      LRR_RI; leucine-rich repeat [structural motif]

    2. NM_171332.5 → NP_741391.2  Leucine-rich repeat protein soc-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741391.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22875
      Conserved Domains (3) summary
      cd00116
      Location:119 → 201
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:75 → 96
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:119 → 176
      LRR_8; Leucine rich repeat

    3. NM_001026088.5 → NP_001021259.1  Leucine-rich repeat protein soc-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021259.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77472, Q22875, Q8MPP6
      Conserved Domains (3) summary
      cd00116
      Location:120 → 202
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:76 → 97
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:120 → 177
      LRR_8; Leucine rich repeat

    4. NM_001306830.4 → NP_001293759.1  Leucine-rich repeat protein SHOC-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293759.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CK98
      Conserved Domains (2) summary
      PLN00113
      Location:68 → 523
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:66 → 87
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22875.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.