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    gcy-25 Receptor-type guanylate cyclase gcy-25 [ Caenorhabditis elegans ]

    Gene ID: 191653, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gcy-25
    Official Full Name
    Receptor-type guanylate cyclase gcy-25
    Primary source
    WormBase:WBGene00001549
    Locus tag
    CELE_Y105C5B.2
    See related
    AllianceGenome:WB:WBGene00001549
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to be active in plasma membrane. Is expressed in neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gcy-25 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    19
    Sequence:
    Chromosome: IV; NC_003282.8 (15872933..15882377)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans. Hallem EA, et al. Proc Natl Acad Sci U S A, 2011 Jan 4. PMID 21173231, Free PMC Article
    2. Invertebrates yield a plethora of atypical guanylyl cyclases. Morton DB. Mol Neurobiol, 2004 Apr. PMID 15126679
    3. Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases. Ortiz CO, et al. Genetics, 2006 May. PMID 16547101, Free PMC Article
    4. High neural activity accelerates the decline of cognitive plasticity with age in Caenorhabditis elegans. Li Q, et al. Elife, 2020 Nov 24. PMID 33228848, Free PMC Article
    5. The neural basis of heat seeking in a human-infective parasitic worm. Bryant AS, et al. Curr Biol, 2022 May 23. PMID 35483361, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Receptor-type guanylate cyclase gcy-25
    NP_001294116.1
    • Confirmed by transcript evidence
    NP_001294117.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      15872933..15882377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307187.2 → NP_001294116.1  Receptor-type guanylate cyclase gcy-25 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294116.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A078BQP2, A0A078BTN7
      Conserved Domains (6) summary
      cd06351
      Location:56 → 230
      PBP1_iGluR_N_LIVBP_like; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NMDA, AMPA, and kainate receptor subtypes of ionotropic glutamate receptors (iGluRs)
      smart00044
      Location:790 → 976
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      COG0515
      Location:474 → 736
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      pfam07701
      Location:764 → 805
      HNOBA; Heme NO binding associated
      cl11967
      Location:812 → 999
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
      cl21453
      Location:473 → 746
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001307188.3 → NP_001294117.1  Receptor-type guanylate cyclase gcy-25 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294117.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A078BQP2
      Conserved Domains (6) summary
      cd06351
      Location:56 → 230
      PBP1_iGluR_N_LIVBP_like; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NMDA, AMPA, and kainate receptor subtypes of ionotropic glutamate receptors (iGluRs)
      smart00044
      Location:737 → 923
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      COG0515
      Location:474 → 625
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      pfam07701
      Location:711 → 752
      HNOBA; Heme NO binding associated
      cl11967
      Location:759 → 946
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
      cl21453
      Location:473 → 693
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A078BQP2.1

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