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    nex-4 Annexin [ Caenorhabditis elegans ]

    Gene ID: 183294, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nex-4
    Official Full Name
    Annexin
    Primary source
    WormBase:WBGene00003591
    Locus tag
    CELE_C37H5.1
    See related
    AllianceGenome:WB:WBGene00003591
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium-dependent phospholipid binding activity and phosphatidylserine binding activity. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Is expressed in intestine and nervous system. Orthologous to human ANXA10 (annexin A10); ANXA8 (annexin A8); and ANXA9 (annexin A9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nex-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (4851472..4857276)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Abhydrolase domain-containing protein abhd-5.2 Neighboring gene Abhydrolase domain-containing protein abhd-5.1 Neighboring gene Acetyltransferase;Acyl-coenzyme A thioesterase 8;RRM_2 domain-containing protein Neighboring gene Serpentine receptor class delta-32 Neighboring gene Serpentine receptor class delta-33 Neighboring gene Gamma-glutamyltranspeptidase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ligand-binding activity and expression profile of annexins in Caenorhabditis elegans. Nishioka S, et al. J Biochem, 2007 Jan. PMID 17169974
    2. Transcription, biochemistry and localization of nematode annexins. Daigle SN, et al. J Cell Sci, 1999 Jun. PMID 10341209
    3. Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD(+) in axon regeneration. Kim KW, et al. Elife, 2018 Nov 21. PMID 30461420, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Annexin
    NP_001309625.1
    • Confirmed by transcript evidence
    NP_001368593.1
    • Confirmed by transcript evidence
    NP_001379788.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4851472..4857276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322553.3 → NP_001309625.1  Annexin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MB16
      Conserved Domains (1) summary
      pfam00191
      Location:305 → 370
      Annexin; Annexin

    2. NM_001380638.1 → NP_001368593.1  Annexin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBL3
      Conserved Domains (1) summary
      pfam00191
      Location:319 → 384
      Annexin

    3. NM_001392506.1 → NP_001379788.1  Annexin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91144
      Conserved Domains (1) summary
      pfam00191
      Location:266 → 331
      Annexin
    Nucleotide Protein
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