arx-1 Actin-related protein 3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: arx-1
Official Full Name: Actin-related protein 3
Primary source: WormBase:WBGene00000199
Locus tag: CELE_Y71F9AL.16
See related: AllianceGenome:WB:WBGene00000199
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Involved in Arp2/3 complex-mediated actin nucleation; embryonic morphogenesis; and epithelial cell migration. Located in cell leading edge and cytoplasm. Is expressed in hypodermis. Human ortholog(s) of this gene implicated in opisthorchiasis. Orthologous to several human genes including ACTR3 (actin related protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See arx-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (2883549..2893718, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arp2/3 is enriched at the cell cortex and is required for stable membrane-cytoskeletal linkages.
Title: In vivo roles for Arp2/3 in cortical actin organization during C. elegans gastrulation.
protein CYK-1 and the profilin PFN-1 mediate the Arp2/3-independent assembly of cortical microfilaments and are required for cytokinesis in the early embryo
Title: A Formin Homology protein and a profilin are required for cytokinesis and Arp2/3-independent assembly of cortical microfilaments in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y71F9A_294.f (e-PCR)
- UniSTS:324480

Y71F9A_294.g (e-PCR)
- UniSTS:323996

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
contributes_to actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Actin-related protein 3

NP_491066.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

2883549..2893718 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058665.8 → NP_491066.1 Actin-related protein 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491066.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9N4I0

Conserved Domains (2) summary

COG5277
Location:7 → 417

COG5277; Actin-related protein [Cytoskeleton]

PTZ00280
Location:3 → 423

PTZ00280; Actin-related protein 3; Provisional