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    sulp-8 STAS domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179357, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sulp-8
    Official Full Name
    STAS domain-containing protein
    Primary source
    WormBase:WBGene00013963
    Locus tag
    CELE_ZK287.2
    See related
    AllianceGenome:WB:WBGene00013963
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable inorganic anion transmembrane transporter activity and organic anion transmembrane transporter activity. Predicted to be involved in chloride transmembrane transport and sulfate transmembrane transport. Located in basolateral plasma membrane. Is expressed in excretory cell and intestine. Human ortholog(s) of this gene implicated in several diseases, including Pendred Syndrome; autosomal recessive nonsyndromic deafness 4; bone disease (multiple); calcium oxalate nephrolithiasis; and diarrhea (multiple). Orthologous to several human genes including SLC26A3 (solute carrier family 26 member 3) and SLC26A4 (solute carrier family 26 member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sulp-8 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (9670028..9673571, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CRC domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Activin_recp domain-containing protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The small GTPase ARF-1.2 is a regulator of unicellular tube formation in Caenorhabditis elegans. Kage-Nakadai E, et al. J Physiol Sci, 2019 Jan. PMID 29704149, Free PMC Article
    2. The abts and sulp families of anion transporters from Caenorhabditis elegans. Sherman T, et al. Am J Physiol Cell Physiol, 2005 Aug. PMID 15814591
    3. Coordinate regulation of gene expression in the C. elegans excretory cell by the POU domain protein CEH-6. Armstrong KR, et al. Mol Genet Genomics, 2010 Jan. PMID 19921263
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables bicarbonate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxalate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicarbonate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inorganic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oxalate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    STAS domain-containing protein
    NP_001256129.1
    • Confirmed by transcript evidence
    NP_001256130.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9670028..9673571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269200.3 → NP_001256129.1  STAS domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256129.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFB2, Q3LTR4
      Conserved Domains (1) summary
      TIGR00815
      Location:33 → 598
      sulP; high affinity sulphate transporter 1

    2. NM_001269201.3 → NP_001256130.1  STAS domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256130.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F5GUB2, Q3LTR4
      Conserved Domains (1) summary
      TIGR00815
      Location:3 → 539
      sulP; high affinity sulphate transporter 1

    RNA

    1. NR_069213.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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