spin-1 Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: spin-1
Official Full Name: Major facilitator superfamily (MFS) profile domain-containing protein
Primary source: WormBase:WBGene00007549
Locus tag: CELE_C13C4.5
See related: AllianceGenome:WB:WBGene00007549
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including excretory cell; nervous system; pharyngeal-intestinal valve; tail; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 115. Orthologous to human SPNS1 (SPNS lysolipid transporter 1, lysophospholipid); SPNS2 (SPNS lysolipid transporter 2, sphingosine-1-phosphate); and SPNS3 (SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See spin-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 8

Sequence:: Chromosome: V; NC_003283.11 (12114993..12117443)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taken together, these results indicate that C13C4.5 may regulate the fertility of C. elegans by changing the size and fat content of lipid droplets by interfering with lysosomal morphology and function
Title: C13C4.5/Spinster, an evolutionarily conserved protein that regulates fertility in C. elegans through a lysosome-mediated lipid metabolism process.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C13C4.5 (e-PCR)
- UniSTS:321215

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Major facilitator superfamily (MFS) profile domain-containing protein

NP_506041.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

12114993..12117443

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073640.5 → NP_506041.1 Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506041.1

Status: REVIEWED

UniProtKB/TrEMBL

O01927

Conserved Domains (1) summary

cd17328
Location:59 → 482

MFS_spinster_like; Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters