U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    tdp-1 Tar DNA-binding protein homolog 1 [ Caenorhabditis elegans ]

    Gene ID: 174436, updated on 2-Nov-2024

    Summary

    Official Symbol
    tdp-1
    Official Full Name
    Tar DNA-binding protein homolog 1
    Primary source
    WormBase:WBGene00006514
    Locus tag
    CELE_F44G4.4
    See related
    AllianceGenome:WB:WBGene00006514
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables chromatin binding activity and single-stranded RNA binding activity. Involved in several processes, including RNA splicing; determination of adult lifespan; and hyperosmotic response. Located in nucleus. Is expressed in several structures, including body wall musculature; intestine; muscle cell; neurons; and pharynx. Used to study amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 10. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See tdp-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (8997825..8999725)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Sarcospan

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hyperosmotic response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Tar DNA-binding protein homolog 1
    NP_001022166.1
    • Confirmed by transcript evidence
    NP_001254189.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8997825..8999725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267260.3NP_001254189.1  Tar DNA-binding protein homolog 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254189.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D0VWM8, Q20414, Q6BEV0
      Conserved Domains (1) summary
      cl17169
      Location:174247
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_001026995.8NP_001022166.1  Tar DNA-binding protein homolog 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022166.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D0VWM8
      Conserved Domains (1) summary
      cl17169
      Location:174247
      RRM_SF; RNA recognition motif (RRM) superfamily

    RNA

    1. NR_151561.1 RNA Sequence

      Status: REVIEWED