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    rab-1 RAB family [ Caenorhabditis elegans ]

    Gene ID: 178620, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rab-1
    Official Full Name
    RAB family
    Primary source
    WormBase:WBGene00004266
    Locus tag
    CELE_C39F7.4
    See related
    AllianceGenome:WB:WBGene00004266
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly and intracellular protein transport. Predicted to be active in endomembrane system. Is expressed in several structures, including hypodermis; intestinal muscle; nervous system; pharynx; and reproductive system. Orthologous to human RAB1A (RAB1A, member RAS oncogene family); RAB1B (RAB1B, member RAS oncogene family); and RAB1C (RAB1C, member RAS oncogene family (pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See rab-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (1262629..1263989, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene HET domain-containing protein;Transmembrane protein Neighboring gene ncRNA Neighboring gene BACK domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis. Zhang W, et al. Nat Struct Mol Biol, 2024 Feb. PMID 38177680
    2. Triggered Golgi membrane enrichment promotes PtdIns(4,5)P2 generation for plasma membrane repair. Meng X, et al. J Cell Biol, 2023 Aug 7. PMID 37158801, Free PMC Article
    3. The VAB-1 Eph receptor tyrosine kinase and SAX-3/Robo neuronal receptors function together during C. elegans embryonic morphogenesis. Ghenea S, et al. Development, 2005 Aug. PMID 16033794
    4. Dissecting worm immunity. Hodgkin J. Nat Immunol, 2004 May. PMID 15116111
    5. Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density. Gracheva EO, et al. Neurosci Lett, 2008 Oct 24. PMID 18721860, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RAB family
    NP_503397.1
    • Product from WormBase gene class rab;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1262629..1263989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070996.7 → NP_503397.1  RAB family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503397.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I7FW32, Q9UAQ6
      Conserved Domains (2) summary
      smart00175
      Location:12 → 175
      RAB; Rab subfamily of small GTPases
      cd01869
      Location:10 → 175
      Rab1_Ypt1; Rab GTPase family 1 includes the yeast homolog Ypt1
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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