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    ech-1.2 Enoyl-CoA hydratase [ Caenorhabditis elegans ]

    Gene ID: 172310, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ech-1.2
    Official Full Name
    Enoyl-CoA hydratase
    Primary source
    WormBase:WBGene00020347
    Locus tag
    CELE_T08B2.7
    See related
    AllianceGenome:WB:WBGene00020347
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable enoyl-CoA hydratase activity and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial fatty acid beta-oxidation multienzyme complex. Is expressed in body wall musculature; hypodermis; intestine; nervous system; and tail. Human ortholog(s) of this gene implicated in mitochondrial trifunctional protein deficiency and steatotic liver disease. Orthologous to human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ech-1.2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (6206955..6211155, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Very Early Transcript Neighboring gene BAAT_C domain-containing protein Neighboring gene Large ribosomal subunit protein uL23m Neighboring gene phenylalanine--tRNA ligase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutation in Caenorhabditis elegans Krüppel-like factor, KLF-3 results in fat accumulation and alters fatty acid composition. Zhang J, et al. Exp Cell Res, 2009 Sep 10. PMID 19427851
    2. Galectin LEC-1 plays a defensive role against damage due to oxidative stress in Caenorhabditis elegans. Takeuchi T, et al. J Biochem, 2013 Nov. PMID 23935187
    3. Identification of innate immunity genes and pathways using a comparative genomics approach. Alper S, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18463287, Free PMC Article
    4. RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans. Akay A, et al. Open Biol, 2013 Nov 20. PMID 24258276, Free PMC Article
    5. Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. O'Rourke SM, et al. PLoS Genet, 2007 Aug. PMID 17676955, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enoyl-CoA hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enoyl-CoA hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial fatty acid beta-oxidation multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial fatty acid beta-oxidation multienzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Enoyl-CoA hydratase
    NP_491789.1
    • Confirmed by transcript evidence
    NP_491790.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6206955..6211155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059388.8 → NP_491789.1  Enoyl-CoA hydratase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491789.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GYT0
      Conserved Domains (4) summary
      cd06558
      Location:60 → 269
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
      TIGR02441
      Location:46 → 780
      fa_ox_alpha_mit; fatty acid oxidation complex, alpha subunit, mitochondrial
      pfam00725
      Location:561 → 656
      3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
      pfam02737
      Location:381 → 559
      3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

    2. NM_059389.6 → NP_491790.1  Enoyl-CoA hydratase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BIC3
      Conserved Domains (4) summary
      cd06558
      Location:34 → 243
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
      TIGR02441
      Location:20 → 754
      fa_ox_alpha_mit; fatty acid oxidation complex, alpha subunit, mitochondrial
      pfam00725
      Location:535 → 630
      3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
      pfam02737
      Location:355 → 533
      3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
    Nucleotide Protein
    Heading Accession and Version

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