U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    chmp-7 Charged multivesicular body protein 7 [ Caenorhabditis elegans ]

    Gene ID: 174442, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    chmp-7
    Official Full Name
    Charged multivesicular body protein 7
    Primary source
    WormBase:WBGene00011976
    Locus tag
    CELE_T24B8.2
    See related
    AllianceGenome:WB:WBGene00011976
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and vesicle budding from membrane. Predicted to be part of ESCRT III complex. Predicted to be active in cytoplasmic side of plasma membrane and multivesicular body. Orthologous to human CHMP7 (charged multivesicular body protein 7). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See chmp-7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (9054972..9056504)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene UBA domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 60S ribosomal protein L32;Large ribosomal subunit protein eL32 Neighboring gene ncRNA Neighboring gene Prothymosin alpha Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Nuclear envelope assembly relies on CHMP-7 in the absence of BAF-LEM-mediated hole closure. Barger SR, et al. J Cell Sci, 2023 Nov 1. PMID 37795681, Free PMC Article
    2. The ESCRT machinery directs quality control over inner nuclear membrane architecture. Shankar R, et al. Cell Rep, 2022 Jan 18. PMID 35045304, Free PMC Article
    3. A membrane reticulum, the centriculum, affects centrosome size and function in Caenorhabditis elegans. Maheshwari R, et al. Curr Biol, 2023 Mar 13. PMID 36693370, Free PMC Article
    4. Roles for the RNA polymerase III regulator MAFR-1 in regulating sperm quality in Caenorhabditis elegans. Hammerquist AM, et al. Sci Rep, 2020 Nov 9. PMID 33168938, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle budding from membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Charged multivesicular body protein 7
    NP_495933.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9054972..9056504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063532.8 → NP_495933.1  Charged multivesicular body protein 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495933.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22718
      Conserved Domains (1) summary
      pfam03357
      Location:217 → 384
      Snf7
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.