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    bre-1 GDP-mannose 4,6 dehydratase 1 [ Caenorhabditis elegans ]

    Gene ID: 177717, updated on 14-Nov-2024

    Summary

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    Official Symbol
    bre-1
    Official Full Name
    GDP-mannose 4,6 dehydratase 1
    Primary source
    WormBase:WBGene00000266
    Locus tag
    CELE_C53B4.7
    See related
    AllianceGenome:WB:WBGene00000266
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GDP-mannose 4,6-dehydratase activity. Involved in GDP-L-fucose biosynthetic process; GDP-mannose metabolic process; and response to toxic substance. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Is expressed in body wall musculature; intestine; and nervous system. Human ortholog(s) of this gene implicated in open-angle glaucoma. Orthologous to human GMDS (GDP-mannose 4,6-dehydratase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See bre-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (8987266..8990444)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene PDZ Domain containing Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene UAA transporter Neighboring gene ncRNA Neighboring gene MLt-TeN (mlt-10) related Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adaptation of the "in-gel release method" to N-glycome analysis of low-milligram amounts of material. Rendić D, et al. Electrophoresis, 2007 Dec. PMID 18041037
    2. Plasticity of the β-trefoil protein fold in the recognition and control of invertebrate predators and parasites by a fungal defence system. Schubert M, et al. PLoS Pathog, 2012. PMID 22615566, Free PMC Article
    3. Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose. Barrows BD, et al. J Biol Chem, 2007 Feb 2. PMID 17135259
    4. Nematotoxicity of Marasmius oreades agglutinin (MOA) depends on glycolipid binding and cysteine protease activity. Wohlschlager T, et al. J Biol Chem, 2011 Sep 2. PMID 21757752, Free PMC Article
    5. Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans. Marroquin LD, et al. Genetics, 2000 Aug. PMID 10924467, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cloning, purification and charactrization of gmd-1
      Title: Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GDP-mannose 4,6-dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP-mannose 4,6-dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP-mannose 4,6-dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' GDP-L-fucose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' GDP-L-fucose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GDP-L-fucose biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GDP-L-fucose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GDP-mannose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GDP-mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in endoplasmic reticulum unfolded protein response HEP PubMed 
    involved_in response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in sarcomere HDA PubMed 
    located_in striated muscle dense body HDA PubMed 

    General protein information

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    Preferred Names
    GDP-mannose 4,6 dehydratase 1
    NP_001076668.1
    • Confirmed by transcript evidence
    NP_001076669.1
    • Confirmed by transcript evidence
    NP_001076670.1
    • Confirmed by transcript evidence
    NP_501563.1
    • Confirmed by transcript evidence
    NP_501564.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8987266..8990444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069162.10 → NP_501563.1  GDP-mannose 4,6 dehydratase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501563.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18801
      Conserved Domains (2) summary
      COG1089
      Location:36 → 375
      Gmd; GDP-D-mannose dehydratase [Cell wall/membrane/envelope biogenesis]
      pfam16363
      Location:39 → 370
      GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase

    2. NM_001083201.4 → NP_001076670.1  GDP-mannose 4,6 dehydratase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076670.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18801
      Conserved Domains (2) summary
      COG1089
      Location:46 → 385
      Gmd; GDP-D-mannose dehydratase [Cell wall/membrane/envelope biogenesis]
      pfam16363
      Location:49 → 380
      GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase

    3. NM_069163.5 → NP_501564.1  GDP-mannose 4,6 dehydratase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501564.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q067Y3, Q067Y4, Q067Y5, Q18801, Q1H8X5, Q1H8X6, Q8T8N2, Q8T8N3
      Conserved Domains (2) summary
      COG1089
      Location:51 → 390
      Gmd; GDP-D-mannose dehydratase [Cell wall/membrane/envelope biogenesis]
      pfam16363
      Location:54 → 385
      GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase

    4. NM_001083200.4 → NP_001076669.1  GDP-mannose 4,6 dehydratase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076669.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18801
      Conserved Domains (2) summary
      COG1089
      Location:34 → 373
      Gmd; GDP-D-mannose dehydratase [Cell wall/membrane/envelope biogenesis]
      pfam16363
      Location:37 → 368
      GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase

    5. NM_001083199.4 → NP_001076668.1  GDP-mannose 4,6 dehydratase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076668.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18801
      Conserved Domains (2) summary
      COG1089
      Location:20 → 359
      Gmd; GDP-D-mannose dehydratase [Cell wall/membrane/envelope biogenesis]
      pfam16363
      Location:23 → 354
      GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18801.3

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