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    tbc-3 Rab-GAP TBC domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177845, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tbc-3
    Official Full Name
    Rab-GAP TBC domain-containing protein
    Primary source
    WormBase:WBGene00009322
    Locus tag
    CELE_F32B6.8
    See related
    AllianceGenome:WB:WBGene00009322
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Located in Golgi apparatus. Is expressed in hermaphrodite distal tip cell; neurons; pharynx; rect_D; and seam cell. Orthologous to human TBC1D22A (TBC1 domain family member 22A) and TBC1D22B (TBC1 domain family member 22B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tbc-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    13
    Sequence:
    Chromosome: IV; NC_003282.8 (9899012..9902513)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Bestrophin homolog 13 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct pathways for export of silencing RNA in Caenorhabditis elegans systemic RNAi. Yoshida K, et al. iScience, 2023 Oct 20. PMID 37854694, Free PMC Article
    2. MON-2, a Golgi protein, promotes longevity by upregulating autophagy through mediating inter-organelle communications. Artan M, et al. Autophagy, 2022 May. PMID 35188063, Free PMC Article
    3. Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions. Kanamori T, et al. EMBO J, 2008 Jun 18. PMID 18497747, Free PMC Article
    4. The long and the short of Wnt signaling in C. elegans. Hardin J, et al. Curr Opin Genet Dev, 2008 Aug. PMID 18625312, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rab-GAP TBC domain-containing protein
    NP_001023164.1
    • Confirmed by transcript evidence
    NP_001023165.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9899012..9902513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027993.4 → NP_001023164.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023164.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JL36
      Conserved Domains (1) summary
      smart00164
      Location:170 → 421
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    2. NM_001027994.4 → NP_001023165.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023165.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45434
      Conserved Domains (1) summary
      smart00164
      Location:190 → 441
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    Nucleotide Protein
    Heading Accession and Version

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