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    • Showing Current items.

    dhs-16 3beta-hydroxysteroid dehydrogenase dhs-16 [ Caenorhabditis elegans ]

    Gene ID: 178983, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhs-16
    Official Full Name
    3beta-hydroxysteroid dehydrogenase dhs-16
    Primary source
    WormBase:WBGene00000979
    Locus tag
    CELE_C10F3.2
    See related
    AllianceGenome:WB:WBGene00000979
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables steroid dehydrogenase activity. Involved in steroid catabolic process. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in head neurons; hypodermis; tail neurons; and terminal bulb. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 13; fundus albipunctatus; and night blindness. Orthologous to several human genes including DHRS9 (dehydrogenase/reductase 9); HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6); and RDH5 (retinol dehydrogenase 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dhs-16 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (5983745..5985509)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene adenylate cyclase Neighboring gene ncRNA Neighboring gene DUF4789 domain-containing protein Neighboring gene Alpha-(1,6)-fucosyltransferase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Steroids as central regulators of organismal development and lifespan. Lee SS, et al. PLoS Biol, 2012. PMID 22505849, Free PMC Article
    2. A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity. Wollam J, et al. PLoS Biol, 2012. PMID 22505847, Free PMC Article
    3. Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan. Mahanti P, et al. Cell Metab, 2014 Jan 7. PMID 24411940, Free PMC Article
    4. Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis. Wang Z, et al. Elife, 2021 Dec 7. PMID 34874004, Free PMC Article
    5. Filarial DAF-12 sense the host serum to resume iL3 development during infection. Bétous R, et al. PLoS Pathog, 2023 Jun. PMID 37339136, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DHS-16 controls DAF-12 activity governing longevity in response to signals from the gonad.
      Title: A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables steroid dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in steroid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3beta-hydroxysteroid dehydrogenase dhs-16
    NP_504554.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5983745..5985509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072153.8 → NP_504554.1  3beta-hydroxysteroid dehydrogenase dhs-16 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504554.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16881
      Conserved Domains (2) summary
      pfam00106
      Location:33 → 228
      adh_short; short chain dehydrogenase
      cl21454
      Location:33 → 319
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16881.1

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