U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    hsp-4 Endoplasmic reticulum chaperone BiP homolog;Heat shock 70 kDa protein D [ Caenorhabditis elegans ]

    Gene ID: 174203, updated on 2-Nov-2024

    Summary

    Official Symbol
    hsp-4
    Official Full Name
    Endoplasmic reticulum chaperone BiP homolog;Heat shock 70 kDa protein D
    Primary source
    WormBase:WBGene00002008
    Locus tag
    CELE_F43E2.8
    See related
    AllianceGenome:WB:WBGene00002008
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in endoplasmic reticulum unfolded protein response. Located in rough endoplasmic reticulum. Is expressed in PVD; hypodermis; intestine; and reproductive system. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See hsp-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (7350112..7352518, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Paired domain-containing protein Neighboring gene NR LBD domain-containing protein Neighboring gene ABC-type antigen peptide transporter Neighboring gene Protein inscuteable homologue C-terminal domain-containing protein Neighboring gene peptide-methionine (S)-S-oxide reductase

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endoplasmic reticulum unfolded protein response HEP PubMed 
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endoplasmic reticulum unfolded protein response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to stress IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    part_of endoplasmic reticulum chaperone complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of endoplasmic reticulum chaperone complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Endoplasmic reticulum chaperone BiP homolog;Heat shock 70 kDa protein D
    NP_001293470.1
    • Confirmed by transcript evidence
    NP_001370395.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7350112..7352518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383885.2NP_001370395.1  Endoplasmic reticulum chaperone BiP homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02085, P20163
      Conserved Domains (1) summary
      PTZ00009
      Location:33643
      PTZ00009; heat shock 70 kDa protein; Provisional
    2. NM_001306541.3NP_001293470.1  Heat shock 70 kDa protein D [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293470.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CL98
      Conserved Domains (1) summary
      PTZ00009
      Location:1310
      PTZ00009; heat shock 70 kDa protein; Provisional