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    ZK632.4 putative mannose-6-phosphate isomerase [ Caenorhabditis elegans ]

    Gene ID: 176388, updated on 2-Nov-2024

    Summary

    Official Symbol
    ZK632.4
    Official Full Name
    putative mannose-6-phosphate isomerase
    Primary source
    WormBase:WBGene00014013
    Locus tag
    CELE_ZK632.4
    See related
    AllianceGenome:WB:WBGene00014013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mannose-6-phosphate isomerase activity. Predicted to be involved in GDP-mannose biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in hypodermis; intestine; and nervous system. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and congenital disorder of glycosylation Ib. Orthologous to human MPI (mannose phosphate isomerase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See ZK632.4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (9805515..9807454, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase RIO3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Gamma-Tubulin Associating Protein

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mannose-6-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mannose-6-phosphate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in GDP-mannose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in GDP-mannose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    putative mannose-6-phosphate isomerase
    NP_499174.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9805515..9807454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066773.7NP_499174.3  putative mannose-6-phosphate isomerase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499174.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34650
      Conserved Domains (2) summary
      COG1482
      Location:1400
      ManA; Mannose-6-phosphate isomerase, class I [Carbohydrate transport and metabolism]
      pfam01238
      Location:2363
      PMI_typeI; Phosphomannose isomerase type I