sar-1 Small COPII coat GTPase SAR1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sar-1
Official Full Name: Small COPII coat GTPase SAR1
Primary source: WormBase:WBGene00022678
Locus tag: CELE_ZK180.4
See related: AllianceGenome:WB:WBGene00022678
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTPase activity. Involved in embryo development. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Human ortholog(s) of this gene implicated in chylomicron retention disease. Orthologous to human SAR1A (secretion associated Ras related GTPase 1A) and SAR1B (secretion associated Ras related GTPase 1B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sar-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 5

Sequence:: Chromosome: IV; NC_003282.8 (4511893..4513319, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sar1 is a novel regulator of endoplasmic reticulum-mitochondrial contact sites in the metazoans.
Title: Sar1, a Novel Regulator of ER-Mitochondrial Contact Sites.
Data suggest that Sar1-GTPase acts as curvature-sensing component of COPII coat complex of endoplasmic reticulum; Sar1-GTPase binds avidly to and is stimulated by bilayers of high curvature; Sar1-GTPase appears necessary for remodeling of bilayers.
Title: Sar1 GTPase Activity Is Regulated by Membrane Curvature.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK180.4 (e-PCR)
- UniSTS:318732

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in membrane organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of COPII vesicle coating	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COPII vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Small COPII coat GTPase SAR1

NP_500582.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

4511893..4513319 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068181.6 → NP_500582.1 Small COPII coat GTPase SAR1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500582.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23445

Conserved Domains (1) summary

cd00879
Location:3 → 193

Sar1; Sar1 is an essential component of COPII vesicle coats