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    D2030.2 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 172511, updated on 2-Nov-2024

    Summary

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    Official Symbol
    D2030.2
    Official Full Name
    ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
    Primary source
    WormBase:WBGene00008412
    Locus tag
    CELE_D2030.2
    See related
    AllianceGenome:WB:WBGene00008412
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in mitochondrial matrix. Is expressed in intestine and rectal gland cell. Human ortholog(s) of this gene implicated in erythropoietic protoporphyria. Orthologous to human CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit X). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See D2030.2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (7574240..7578537)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene putative glycerol-3-phosphate dehydrogenase, mitochondrial Neighboring gene ncRNA Neighboring gene alpha-1,2-Mannosidase Neighboring gene Fanconi anemia group I protein Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans. Sendoel A, et al. Cell Death Differ, 2019 Oct. PMID 30728462, Free PMC Article
    2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    3. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
    NP_001021076.1
    • Confirmed by transcript evidence
    NP_001379407.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7574240..7578537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025905.6 → NP_001021076.1  ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021076.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P90788
      Conserved Domains (3) summary
      smart01086
      Location:472 → 555
      ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
      PRK05342
      Location:94 → 570
      clpX; ATP-dependent protease ATP-binding subunit ClpX; Provisional
      pfam07724
      Location:257 → 464
      AAA_2; AAA domain (Cdc48 subfamily)

    2. NM_001392577.1 → NP_001379407.1  ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YTG7
      Conserved Domains (1) summary
      PRK05342
      Location:12 → 454
      clpX; ATP-dependent Clp protease ATP-binding subunit ClpX
    Nucleotide Protein
    Heading Accession and Version

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