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    T24B8.7 UBA domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174440, updated on 2-Nov-2024

    Summary

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    Official Symbol
    T24B8.7
    Official Full Name
    UBA domain-containing protein
    Primary source
    WormBase:WBGene00011980
    Locus tag
    CELE_T24B8.7
    See related
    AllianceGenome:WB:WBGene00011980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Y-linked spermatogenic failure 2; female-restricted syndromic X-linked intellectual disability 99; and non-syndromic X-linked intellectual disability 99. Orthologous to several human genes including USP24 (ubiquitin specific peptidase 24). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See T24B8.7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    29
    Sequence:
    Chromosome: II; NC_003280.10 (9041510..9053664, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific] Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Charged multivesicular body protein 7 Neighboring gene 60S ribosomal protein L32;Large ribosomal subunit protein eL32

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UBA domain-containing protein
    NP_001293493.1
    • Confirmed by transcript evidence
    NP_001293495.1
    • Confirmed by transcript evidence
    NP_001368176.1
    • Partially confirmed by transcript evidence
    NP_001368177.1
    • Confirmed by transcript evidence
    NP_001368178.1
    • Confirmed by transcript evidence
    NP_001368179.1
    • Partially confirmed by transcript evidence
    NP_495931.4
    • Partially confirmed by transcript evidence
    NP_495932.4
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9041510..9053664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063531.7 → NP_495932.4  UBA domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495932.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGM9
      Conserved Domains (3) summary
      smart00165
      Location:133 → 168
      UBA; Ubiquitin associated domain
      cd02659
      Location:1819 → 2234
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1819 → 2229
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. NM_063530.6 → NP_495931.4  UBA domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495931.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG81
      Conserved Domains (3) summary
      smart00165
      Location:133 → 168
      UBA; Ubiquitin associated domain
      cd02659
      Location:1819 → 2234
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1819 → 2229
      UCH; Ubiquitin carboxyl-terminal hydrolase

    3. NM_001306566.3 → NP_001293495.1  UBA domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293495.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      N1NVC2
      Conserved Domains (3) summary
      smart00165
      Location:78 → 113
      UBA; Ubiquitin associated domain
      cd02659
      Location:1764 → 2179
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1764 → 2174
      UCH; Ubiquitin carboxyl-terminal hydrolase

    4. NM_001306564.3 → NP_001293493.1  UBA domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293493.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      N1NTH7
      Conserved Domains (3) summary
      smart00165
      Location:78 → 113
      UBA; Ubiquitin associated domain
      cd02659
      Location:1764 → 2179
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1764 → 2174
      UCH; Ubiquitin carboxyl-terminal hydrolase

    5. NM_001381549.1 → NP_001368177.1  UBA domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      N1NTM2
      Conserved Domains (1) summary
      smart00165
      Location:78 → 113
      UBA; Ubiquitin associated domain

    6. NM_001381547.1 → NP_001368179.1  UBA domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      N1NV23
      Conserved Domains (1) summary
      smart00165
      Location:133 → 168
      UBA; Ubiquitin associated domain

    7. NM_001381548.1 → NP_001368176.1  UBA domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      N1NVC1
      Conserved Domains (1) summary
      smart00165
      Location:133 → 168
      UBA; Ubiquitin associated domain

    8. NM_001381550.1 → NP_001368178.1  UBA domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      N1NSH8
      Conserved Domains (1) summary
      smart00165
      Location:78 → 113
      UBA; Ubiquitin associated domain
    Nucleotide Protein
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