unc-129 BMP-like protein unc-129 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-129
Official Full Name: BMP-like protein unc-129
Primary source: WormBase:WBGene00006852
Locus tag: CELE_C53D6.2
See related: AllianceGenome:WB:WBGene00006852
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables signaling receptor binding activity. Involved in several processes, including axon guidance; backward locomotion; and inductive cell migration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including body wall musculature; nervous system; pm8; spermatheca; and vulF. Orthologous to human GDF10 (growth differentiation factor 10). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-129 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 5

Sequence:: Chromosome: IV; NC_003282.8 (9002839..9005410, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The temporal distribution of UNC-130 protein in body wall muscle cells during embryogenesis is required to establish the dorsal-ventral polarity of UNC-129/TGF-beta, but UNC-130 is not required post-embryonically to maintain the asymmetry of body wall muscle unc-129 expression.
Title: Regulation of UNC-130/FOXD-mediated mesodermal patterning in C. elegans.
UNC-129, graded opposite to UNC-6/netrin, functions independent of the canonical TGF-beta receptors to regulate UNC-5 cellular responses
Title: UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C53D6.2 (e-PCR)
- UniSTS:307382

STS4-161 (e-PCR)
- UniSTS:242151

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transforming growth factor beta receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in backward locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inductive cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode male tail tip morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: BMP-like protein unc-129

NP_501566.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

9002839..9005410 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069165.8 → NP_501566.1 BMP-like protein unc-129 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501566.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EBY8

Conserved Domains (1) summary

smart00204
Location:312 → 406

TGFB; Transforming growth factor-beta (TGF-beta) family