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    haf-1 HAlF transporter (PGP related) [ Caenorhabditis elegans ]

    Gene ID: 178522, updated on 9-Dec-2024

    Summary

    Official Symbol
    haf-1
    Official Full Name
    HAlF transporter (PGP related)
    Primary source
    WormBase:WBGene00001811
    Locus tag
    CELE_C30H6.6
    See related
    AllianceGenome:WB:WBGene00001811
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables peptide transmembrane transporter activity. Involved in mitochondrial unfolded protein response; peptide transport; and protein import into mitochondrial matrix. Located in mitochondrial inner membrane. Orthologous to human ABCB10 (ATP binding cassette subfamily B member 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See haf-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (17376427..17379310)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Apple domain-containing protein Neighboring gene Altered inheritance of mitochondria protein 36, mitochondrial Neighboring gene 2-oxoacid dehydrogenase acyltransferase catalytic domain-containing protein Neighboring gene protein-disulfide reductase

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATPase-coupled transmembrane transporter activity  
    enables peptide transmembrane transporter activity PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial unfolded protein response PubMed 
    involved_in peptide transport PubMed 
    involved_in protein import into mitochondrial matrix PubMed 
    involved_in response to chemical  
    involved_in transmembrane transport  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    is_active_in membrane  
    located_in membrane  
    located_in mitochondrial inner membrane PubMed 

    General protein information

    Preferred Names
    HAlF transporter (PGP related)
    NP_503098.2
    • Product from WormBase gene class haf;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      17376427..17379310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070697.7NP_503098.2  HAlF transporter (PGP related) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503098.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45278
      Conserved Domains (3) summary
      COG1132
      Location:82641
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      cl00549
      Location:93363
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:413641
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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